Tyr413
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Home > Phosphorylation Site Page: > Tyr413  -  GABRG2 (mouse)

Site Information
ERDEEyGyECLDGKD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455818

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' [GABRG2 (mouse), genetic knockin] ( 2 ) , 'neuron, hippocampal'-brain ( 1 )

Upstream Regulation
Putative in vivo kinases:
Fyn (mouse) ( 1 )
Kinases, in vitro:
Fyn (human) ( 1 ) , Src (human) ( 1 )
Treatments:
vanadate ( 1 )

Downstream Regulation
Effects of modification on GABRG2:
activity, induced ( 2 ) , receptor internalization, altered ( 2 )

References 

1

Jurd R, et al. (2010) Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Mol Cell Neurosci 44, 129-34
20233604   Curated Info

2

Tretter V, et al. (2009) Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc Natl Acad Sci U S A 106, 20039-44
19903874   Curated Info