Tyr413
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Home > Phosphorylation Site Page: > Tyr413  -  GABRG2 (rat)

Site Information
ERDEEyGyECLDGKD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455818

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cerebellar granule'-brain ( 2 ) , 'neuron, cortical' ( 1 ) , 'neuron, cortical'-brain ( 2 )

Upstream Regulation
Kinases, in vitro:
Src (rat) ( 2 )
Treatments:
vanadate ( 2 )

Downstream Regulation
Effects of modification on GABRG2:
molecular association, regulation ( 1 , 2 ) , receptor internalization, inhibited ( 1 )
Effects of modification on biological processes:
endocytosis, inhibited ( 1 ) , neural plasticity ( 1 )
Induce interaction with:
Src (rat) ( 2 )
Inhibit interaction with:
AP-2 alpha (human) ( 1 )

References 

1

Kittler JT, et al. (2008) Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit. Proc Natl Acad Sci U S A 105, 3616-21
18305175   Curated Info

2

Brandon NJ, et al. (2001) Constitutive tyrosine phosphorylation of the GABA(A) receptor gamma 2 subunit in rat brain. Neuropharmacology 41, 745-52
11640929   Curated Info