Tyr166
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Home > Phosphorylation Site Page: > Tyr166  -  MOR-1 (rat)

Site Information
CTMSVDRyIAVCHPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455805

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , oocyte [CPEB (mouse)] ( 2 )

Upstream Regulation
Treatments:
DAMGO ( 1 ) , EGF ( 1 ) , H2O2 ( 1 ) , naloxone ( 1 ) , PP2 ( 1 )

Downstream Regulation
Effects of modification on MOR-1:
activity, inhibited ( 1 , 2 )

References 

1

Clayton CC, Bruchas MR, Lee ML, Chavkin C (2010) Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy. Mol Pharmacol 77, 339-47
19959593   Curated Info

2

McLaughlin JP, Chavkin C (2001) Tyrosine phosphorylation of the mu-opioid receptor regulates agonist intrinsic efficacy. Mol Pharmacol 59, 1360-8
11353794   Curated Info