Ser264
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Home > Phosphorylation Site Page: > Ser264  -  AQP2 (human)

Site Information
VELHsPQsLPRGtkA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2238600

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , immunoassay ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 2 ) , mpkCCD (renal) ( 3 ) , Pichia pastoris (yeast cell) ( 2 ) , urine ( 1 )

Upstream Regulation
Treatments:
vasopressin ( 3 )

Downstream Regulation
Effects of modification on AQP2:
intracellular localization ( 3 )
Effects of modification on biological processes:
exocytosis, induced ( 1 )

References 

1

Sakai M, et al. (2020) Phosphorylation profile of human AQP2 in urinary exosomes by LC-MS/MS phosphoproteomic analysis. Clin Exp Nephrol
32529500   Curated Info

2

Roche JV, et al. (2017) Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5. J Biol Chem 292, 14636-14648
28710278   Curated Info

3

Trimpert C, et al. (2012) Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus. Nephrol Dial Transplant 27, 4389-97
22778181   Curated Info