Tyr146
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Home > Phosphorylation Site Page: > Tyr146  -  DOK1 (human)

Site Information
EMLENSLySPTWEGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455786
Associated spectra:  2 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
leukemia ( 3 ) , acute myelogenous leukemia ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
CD2 (human) ( 2 )

Downstream Regulation
Effects of modification on DOK1:
molecular association, regulation ( 2 )
Induce interaction with:
DOK1 (human) ( 2 ) , DOK2 (human) ( 2 )

References 

1

Possemato A (2006) CST Curation Set: 2120; Year: 2006; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Boulay I, NĂ©morin JG, Duplay P (2005) Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation. J Immunol 175, 4483-9
16177091   Curated Info

3

Gu T (2005) CST Curation Set: 758; Year: 2005; Biosample/Treatment: cell line, UT-7/elastase; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info