Ser65
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Home > Phosphorylation Site Page: > Ser65  -  TBCB (human)

Site Information
GVDDKFYskLDQEDA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455784

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 2 ) , mutation of modification site ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PAK1 (human) ( 2 )
Kinases, in vitro:
PAK1 (human) ( 2 )
Treatments:
EGF ( 2 ) , siRNA ( 2 ) , SNP ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 , 2 )

References 

1

Rayala SK, et al. (2007) Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. Proc Natl Acad Sci U S A 104, 19470-5
18048340   Curated Info

2

Vadlamudi RK, et al. (2005) p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Mol Cell Biol 25, 3726-36
15831477   Curated Info