Thr253
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Home > Phosphorylation Site Page: > Thr253  -  TBC1D1 (mouse)

Site Information
DASLRSStFssFDND   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2228805

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 7 ) , brain ( 2 ) , C2C12 (myoblast) ( 3 , 4 , 5 , 6 ) , kidney ( 2 ) , lung ( 2 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 1 ) , spleen ( 2 ) , testis ( 2 )

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (mouse) ( 7 )
Kinases, in vitro:
Akt1 (human) ( 7 ) , AMPKA1 (human) ( 7 )
Treatments:
acadesine ( 7 ) , insulin ( 7 ) , muscle contraction ( 7 )

References 

1

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Possemato A (2008) CST Curation Set: 5257; Year: 2008; Biosample/Treatment: cell line, C2C12/serum starved; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

4

Possemato A (2008) CST Curation Set: 5258; Year: 2008; Biosample/Treatment: cell line, C2C12/serum starved; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

5

Possemato A (2008) CST Curation Set: 5259; Year: 2008; Biosample/Treatment: cell line, C2C12/serum starved; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

6

Possemato A (2008) CST Curation Set: 5260; Year: 2008; Biosample/Treatment: cell line, C2C12/serum starved; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

7

Taylor EB, et al. (2008) Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. J Biol Chem 283, 9787-96
18276596   Curated Info