Ser391
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Home > Phosphorylation Site Page: > Ser391  -  BARD1 (human)

Site Information
SDEFISLsPGtPPSt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455774

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 8 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 , 8 ) , mutation of modification site ( 8 )
Disease tissue studied:
breast cancer ( 8 ) , cervical cancer ( 5 ) , cervical adenocarcinoma ( 5 ) , colorectal cancer ( 8 ) , colorectal carcinoma ( 8 ) , lung cancer ( 8 ) , non-small cell lung cancer ( 8 )
Relevant cell line - cell type - tissue:
HCC1937 (breast cell) ( 8 ) , HCT116 (intestinal) ( 8 ) , HeLa (cervical) ( 1 , 4 , 7 , 8 ) , HeLa S3 (cervical) ( 5 ) , Jurkat (T lymphocyte) ( 2 , 6 ) , NCI-H1299 (pulmonary) ( 8 )

Upstream Regulation
Treatments:
nocodazole ( 5 , 8 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 8 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

5

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

6

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

7

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

8

Choudhury AD, et al. (2005) Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. J Biol Chem 280, 24669-79
15855157   Curated Info

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