Thr394
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Home > Phosphorylation Site Page: > Thr394  -  BARD1 (human)

Site Information
FISLsPGtPPStLSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455773

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 9 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 ) , mutation of modification site ( 9 )
Disease tissue studied:
breast cancer ( 9 ) , cervical cancer ( 6 ) , cervical adenocarcinoma ( 6 ) , colorectal cancer ( 9 ) , colorectal carcinoma ( 9 ) , lung cancer ( 9 ) , non-small cell lung cancer ( 9 )
Relevant cell line - cell type - tissue:
HCC1937 (breast cell) ( 9 ) , HCT116 (intestinal) ( 9 ) , HeLa (cervical) ( 1 , 5 , 8 , 9 ) , HeLa S3 (cervical) ( 6 ) , Jurkat (T lymphocyte) ( 2 , 4 , 7 ) , NCI-H1299 (pulmonary) ( 9 )

Upstream Regulation
Treatments:
nocodazole ( 6 , 9 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 9 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Zhou J (2011) CST Curation Set: 12496; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

7

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

8

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

9

Choudhury AD, et al. (2005) Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. J Biol Chem 280, 24669-79
15855157   Curated Info

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