Ser148
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Home > Phosphorylation Site Page: > Ser148  -  BARD1 (human)

Site Information
NSIkMWFsPRSkKVR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455770

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 8 ) , mass spectrometry ( 2 , 4 , 5 , 6 , 7 , 8 ) , mutation of modification site ( 1 , 8 , 9 )
Disease tissue studied:
bone cancer ( 1 ) , breast cancer ( 2 , 8 ) , breast cancer, triple negative ( 2 ) , cervical cancer ( 6 ) , cervical adenocarcinoma ( 6 ) , colorectal cancer ( 8 ) , colorectal carcinoma ( 8 ) , lung cancer ( 8 ) , non-small cell lung cancer ( 8 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , HCC1937 (breast cell) ( 8 ) , HCT116 (intestinal) ( 8 ) , HEK293T (epithelial) ( 9 ) , HeLa (cervical) ( 4 , 5 , 7 , 8 ) , HeLa S3 (cervical) ( 6 ) , NCI-H1299 (pulmonary) ( 8 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 9 ) , CDK2 (human) ( 9 )
Treatments:
BI_4834 ( 4 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 8 )

References 

1

Daza-Martin M, et al. (2019) Isomerization of BRCA1-BARD1 promotes replication fork protection. Nature 571, 521-527
31270457   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

Grosstessner-Hain K, et al. (2011) Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics 10, M111.008540
21857030   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

7

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

8

Choudhury AD, et al. (2005) Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. J Biol Chem 280, 24669-79
15855157   Curated Info

9

Hayami R, et al. (2005) Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. Cancer Res 65, 6-10
15665273   Curated Info

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