Ser251
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Home > Phosphorylation Site Page: > Ser251  -  BARD1 (human)

Site Information
sQPSVISsPQINGEI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455769

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 2 , 3 )
Disease tissue studied:
breast cancer ( 2 ) , colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:
HCC1937 (breast cell) ( 2 ) , HCT116 (intestinal) ( 2 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 1 ) , NCI-H1299 (pulmonary) ( 2 )

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 3 ) , CDK2 (human) ( 3 )
Treatments:
nocodazole ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

Possemato A (2007) CST Curation Set: 2657; Year: 2007; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y)XpSAntibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) Arg-X-Tyr/Phe-X-pSer Motif Antibody Cat#: 2981
Curated Info

2

Choudhury AD, et al. (2005) Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. J Biol Chem 280, 24669-79
15855157   Curated Info

3

Hayami R, et al. (2005) Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. Cancer Res 65, 6-10
15665273   Curated Info

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