Tyr198

Site Information
EERKEDQyMKMtVCL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455758

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:	gastric cancer ( 1 ) , gastric carcinoma ( 1 )
Relevant cell line - cell type - tissue:	HEK293-A (epithelial) ( 2 ) , MKN-45 (gastric) ( 1 )

Upstream Regulation
Kinases, in vitro:	INSR (human) ( 2 )

Downstream Regulation
Effects of modification on BVR:	enzymatic activity, induced ( 2 )

References
1	Mulhern D (2011) CST Curation Set: 12645; Year: 2011; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Lerner-Marmarosh N, et al. (2005) Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc Natl Acad Sci U S A 102, 7109-14 15870194 Curated Info

References

Mulhern D (2011) CST Curation Set: 12645; Year: 2011; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

Lerner-Marmarosh N, et al. (2005) Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc Natl Acad Sci U S A 102, 7109-14
15870194 Curated Info