Thr192
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Home > Phosphorylation Site Page: > Thr192  -  Claudin-3 (human)

Site Information
PPREKKytAtkVVys   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455751

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 1 )

Downstream Regulation
Effects of modification on Claudin-3:
activity, inhibited ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 1 )

References 

1

D'Souza T, Agarwal R, Morin PJ (2005) Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem 280, 26233-40
15905176   Curated Info