Tyr783
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Home > Phosphorylation Site Page: > Tyr783  -  PLCG1 (cow)

Site Information
EGRNPGFyVEANPMP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447667

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
BAEC (endothelial) ( 1 ) , DT40 (B lymphocyte) ( 3 ) , Jurkat (T lymphocyte) ( 2 , 3 )

Upstream Regulation
Kinases, in vitro:
EGFR (human) ( 4 )
Treatments:
angiopoietin-1 ( 1 ) , anti-CD3 ( 2 , 3 ) , anti-IgM ( 3 ) , VEGF ( 1 )

Downstream Regulation
Effects of modification on PLCG1:
enzymatic activity, induced ( 3 )
Effects of modification on biological processes:
transcription, altered ( 3 )

References 

1

Oubaha M, Gratton JP (2009) Phosphorylation of endothelial nitric oxide synthase by atypical PKC zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro. Blood 114, 3343-51
19564638   Curated Info

2

Braiman A, Barda-Saad M, Sommers CL, Samelson LE (2006) Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains. EMBO J 25, 774-84
16467851   Curated Info

3

Serrano CJ, et al. (2005) A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling. J Immunol 174, 6233-7
15879121   Curated Info

4

Fry DW, et al. (1994) Design of a potent peptide inhibitor of the epidermal growth factor receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase C-gamma 1. Peptides 15, 951-7
7991458   Curated Info