Ser123
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Home > Phosphorylation Site Page: > Ser123  -  osteopontin (human)

Site Information
DsHQsDEsHHsDEsD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455738

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
MC3T3-E1 (preosteoblast) ( 2 ) , milk ( 3 , 4 ) , urine ( 3 )

Downstream Regulation
Effects of modification on osteopontin:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 )
Induce interaction with:
Other ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
X-linked hypophosphatemia ( 2 )

References 

1

Yalak G, et al. (2019) Phosphorylated fibronectin enhances cell attachment and upregulates mechanical cell functions. PLoS One 14, e0218893
31291285   Curated Info

2

Addison WN, Masica DL, Gray JJ, McKee MD (2010) Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage. J Bone Miner Res 25, 695-705
19775205   Curated Info

3

Christensen B, Petersen TE, Sørensen ES (2008) Post-translational modification and proteolytic processing of urinary osteopontin. Biochem J 411, 53-61
18072945   Curated Info

4

Christensen B, et al. (2005) Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. Biochem J 390, 285-92
15869464   Curated Info