Thr93
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Home > Phosphorylation Site Page: > Thr93  -  MBP iso5 (mouse)

Site Information
HFFKNIVtPRtPPPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455362

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , N19 OLGs (oligodendrocyte) ( 2 )

Downstream Regulation
Effects of modification on MBP iso5:
intracellular localization ( 2 ) , molecular association, regulation ( 1 , 2 ) , protein conformation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )
Inhibit interaction with:
Fyn (human) ( 2 )

References 

1

Vassall KA, et al. (2013) The Effects of Threonine Phosphorylation on the Stability and Dynamics of the Central Molecular Switch Region of 18.5-kDa Myelin Basic Protein. PLoS One 8, e68175
23861868   Curated Info

2

Smith GS, et al. (2012) Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes. J Neurosci Res 90, 28-47
21887699   Curated Info