Ser4
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Home > Phosphorylation Site Page: > Ser4  -  CK2B (human)

Site Information
____MsssEEVsWIS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455683

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 ) , mutation of modification site ( 7 )
Disease tissue studied:
cervical cancer ( 3 ) , cervical adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:
A498 (renal) ( 2 ) , COS (fibroblast) ( 7 ) , Flp-In T-Rex-293 (epithelial) ( 1 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 1 ) , HCT116 (intestinal) ( 5 ) , HeLa (cervical) ( 4 ) , HeLa S3 (cervical) ( 3 , 6 ) , MDA-MB-435S (breast cell) ( 5 ) , MV4-11 (macrophage) ( 5 ) , U2OS (bone cell) [GR (human)] ( 7 )

Upstream Regulation
Treatments:
nocodazole ( 3 )

Downstream Regulation
Effects of modification on CK2B:
protein stabilization ( 7 )

References 

1

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

2

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

3

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

4

Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808
19651622   Curated Info

5

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

6

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

7

Zhang C, Vilk G, Canton DA, Litchfield DW (2002) Phosphorylation regulates the stability of the regulatory CK2beta subunit. Oncogene 21, 3754-64
12032843   Curated Info