Tyr1495
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Home > Phosphorylation Site Page: > Tyr1495  -  SCN5A (human)

Site Information
TEEQKkyyNAMKKLG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455660

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 2 )
Kinases, in vitro:
Fyn (human) ( 2 )

Downstream Regulation
Effects of modification on SCN5A:
activity, induced ( 1 ) , activity, inhibited ( 2 ) , protein conformation ( 1 )

References 

1

Galleano I, et al. (2021) Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na1.5. Proc Natl Acad Sci U S A 118
34373326   Curated Info

2

Ahern CA, Zhang JF, Wookalis MJ, Horn R (2005) Modulation of the cardiac sodium channel NaV1.5 by Fyn, a Src family tyrosine kinase. Circ Res 96, 991-8
15831816   Curated Info