Ser434

Site Information
sIAGIIRsPKSALGS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2192594

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 3 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 )
Disease tissue studied:	cervical cancer ( 10 ) , cervical adenocarcinoma ( 10 ) , colorectal cancer ( 13 ) , colorectal carcinoma ( 13 )
Relevant cell line - cell type - tissue:	A498 (renal) ( 9 ) , HCT116 (intestinal) ( 11 , 13 ) , HeLa (cervical) ( 1 , 5 , 7 ) , HeLa S3 (cervical) ( 10 , 12 ) , HeLa_Meta (cervical) ( 8 ) , HeLa_Pro (cervical) ( 8 ) , HeLa_Telo (cervical) ( 8 ) , Jurkat (T lymphocyte) ( 3 ) , K562 (erythroid) ( 5 ) , MDA-MB-435S (breast cell) ( 11 ) , MV4-11 (macrophage) ( 11 )

Upstream Regulation
Treatments:	MG132_withdrawal ( 8 ) , nocodazole ( 12 ) , thymidine ( 12 )

References
1	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
4	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
5	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
6	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
7	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
8	Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81 20097925 Curated Info
9	Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62 20071362 Curated Info
10	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
11	Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64 19369195 Curated Info
12	Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48 18691976 Curated Info
13	Wissing J, et al. (2007) Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics 6, 537-47 17192257 Curated Info