Lys115
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Home > Ubiquitylation Site Page: > Lys115  -  RIPK1 (human)

Site Information
MSTPLSVkGRIILEI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2188101

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mass spectrometry ( 2 , 3 ) , modification-specific antibody ( 3 ) , multiple reaction monitoring (MRM) ( 3 ) , mutation of modification site ( 2 ) , western blotting ( 3 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , HEK293T (epithelial) ( 3 ) , HT-29 (intestinal) ( 2 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Treatments:
Necrostatin-1 ( 2 ) , TNF ( 2 ) , Z-VAD-FMK ( 2 )

Downstream Regulation
Effects of modification on RIPK1:
phosphorylation ( 2 )
Effects of modification on biological processes:
signaling pathway regulation ( 2 ) , transcription, induced ( 2 )

References 

1

Feltham R, et al. (2018) Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. Cell Rep
29642005   Curated Info

2

de Almagro MC, et al. (2017) Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death. Cell Death Differ 24, 26-37
27518435   Curated Info

3

Mollah S, et al. (2007) Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins. Rapid Commun Mass Spectrom 21, 3357-64
17883243   Curated Info

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