Thr200
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Home > Phosphorylation Site Page: > Thr200  -  TIF1A (human)

Site Information
IARYVPstPWFLMPI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455599

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phosphoamino acid analysis ( 1 ) , phosphopeptide mapping ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
JNK2 (human) ( 1 )
Treatments:
anisomycin ( 1 ) , H2O2 ( 1 )

Downstream Regulation
Effects of modification on TIF1A:
activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Inhibit interaction with:
POLR1B (human) ( 1 ) , TAF1B (human) ( 1 )

References 

1

Mayer C, Bierhoff H, Grummt I (2005) The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 19, 933-41
15805466   Curated Info