Ser401
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Home > Phosphorylation Site Page: > Ser401  -  GATA2 (human)

Site Information
QTRNRKMsNKSKKSK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455583

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 1 )
Treatments:
insulin ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on GATA2:
activity, inhibited ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 1 ) , transcription, altered ( 1 )

References 

1

Menghini R, et al. (2005) Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 111, 1946-53
15837948   Curated Info