Tyr177
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Home > Phosphorylation Site Page: > Tyr177  -  ephexin-1 (mouse)

Site Information
IEQIGLLyQEyRDKS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455579

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 2 ) , 'neuron, striatal'-brain ( 3 ) , 293 (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , L6 (myoblast) ( 1 ) , REF52 (fibroblast) ( 3 ) , retinal ganglion ( 3 )

Upstream Regulation
Putative in vivo kinases:
FGFR2 (human) ( 1 ) , Src iso1 (mouse) ( 3 )
Kinases, in vitro:
EphA4 (human) ( 3 ) , Src (human) ( 3 )
Treatments:
BDNF ( 3 ) , colforsin ( 3 ) , EGF ( 3 ) , ephrin_A1 ( 2 , 3 ) , ephrin_B3 ( 2 , 3 ) , LPA ( 3 ) , Nogo ( 3 ) , PDGF ( 3 ) , PP2 ( 1 , 3 ) , PP3 ( 3 ) , Sem3A ( 3 ) , SU5402 ( 1 ) , SU6656 ( 3 ) , vanadate ( 1 , 3 )

Downstream Regulation
Effects of modification on ephexin-1:
activity, induced ( 3 )
Effects of modification on biological processes:
cell motility, altered ( 3 ) , cytoskeletal reorganization ( 3 )

References 

1

Zhang Y, et al. (2007) Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation. J Biol Chem 282, 31103-12
17702745   Curated Info

2

Egea J, et al. (2005) Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron 47, 515-28
16102535   Curated Info

3

Sahin M, et al. (2005) Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron 46, 191-204
15848799   Curated Info

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