Thr32
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Home > Phosphorylation Site Page: > Thr32  -  FOXO4 (mouse)

Site Information
QSRPRSCtWPLPRPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455572

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 3 , 4 , 5 ) , kidney ( 2 ) , lung ( 2 ) , spleen ( 2 )

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 6 )

Downstream Regulation
Effects of modification on FOXO4:
molecular association, regulation ( 6 )
Effects of modification on biological processes:
transcription, altered ( 6 )
Induce interaction with:
14-3-3 zeta (human) ( 6 )

References 

1

Zhou B, et al. (2021) Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase. Cell Rep 37, 109785
34610303   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Tucker M (2009) CST Curation Set: 8604; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

4

Tucker M (2009) CST Curation Set: 8603; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

5

Tucker M (2009) CST Curation Set: 8602; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

6

Obsil T, et al. (2003) Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry 42, 15264-72
14690436   Curated Info

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