Ser66
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Home > Phosphorylation Site Page: > Ser66  -  RARG iso2 (mouse)

Site Information
SEEMVPSsPsPPPPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455543

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 , 2 ) , F9 (testicular) ( 1 )

Upstream Regulation
Putative in vivo kinases:
P38A (mouse) ( 1 )
Treatments:
imatinib ( 1 ) , LY294002 ( 1 ) , retinoic_acid ( 1 ) , SB203580 ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on RARG iso2:
activity, induced ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 )

References 

1

Gianni M, et al. (2002) Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2. J Biol Chem 277, 24859-62
12032135   Curated Info

2

Bastien J, et al. (2000) TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7. J Biol Chem 275, 21896-904
10748061   Curated Info

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