Tyr47

Site Information
SGQISNGysAVPSPG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 21697923

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:	lung cancer ( 2 ) , non-small cell squamous cell lung carcinoma ( 2 )
Relevant cell line - cell type - tissue:	HTR (mast) ( 1 ) , lung ( 2 )

Upstream Regulation
Putative in vivo kinases:	Src (human) ( 1 )
Treatments:	PP2 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on SERT:	activity, induced ( 1 ) , protein stabilization ( 1 )

References
1	Annamalai B, et al. (2012) Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Mol Pharmacol 81, 73-85 21992875 Curated Info
2	Ren H (2009) CST Curation Set: 7178; Year: 2009; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell squamous cell lung carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

References

Annamalai B, et al. (2012) Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Mol Pharmacol 81, 73-85
21992875 Curated Info

Ren H (2009) CST Curation Set: 7178; Year: 2009; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell squamous cell lung carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info