Ser155
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Home > Phosphorylation Site Page: > Ser155  -  Ku70 (human)

Site Information
WVCANLFsDVQFKMS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21691607

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) ( 1 , 2 )

Upstream Regulation
Treatments:
ionizing_radiation ( 1 , 2 )

Downstream Regulation
Effects of modification on Ku70:
phosphorylation ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , cell cycle regulation ( 1 )
Induce interaction with:
AurB (human) ( 1 )

References 

1

Fell VL, et al. (2016) Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response. Sci Rep 6, 37194
27849008   Curated Info

2

Fell VL, Schild-Poulter C (2012) Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain. Mol Cell Biol 32, 76-87
22037767   Curated Info