Ser496
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Home > Phosphorylation Site Page: > Ser496  -  ERK5 (mouse)

Site Information
SRLRDGPsAPLEAPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455518

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 4 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 4 ) , endothelial-aorta ( 2 ) , HeLa (cervical) ( 3 ) , HUVEC (endothelial) ( 2 , 3 ) , macrophage-bone marrow ( 1 ) , monocyte-blood ( 1 )

Upstream Regulation
Putative in vivo kinases:
p90RSK (human) ( 3 )
Kinases, in vitro:
p90RSK (mouse) ( 3 )
Treatments:
atazanavir ( 1 ) , cART ( 1 ) , FMK-MEA ( 1 , 2 , 3 ) , H2O2 ( 1 , 3 ) , ionizing_radiation ( 2 ) , Maraviroc ( 1 ) , ritonavir ( 1 ) , Tenofovir ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , transcription, induced ( 2 ) , transcription, inhibited ( 1 , 3 )

References 

1

Singh MV, et al. (2018) Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV Individuals: Implications for Atherogenesis. Circulation
30586719   Curated Info

2

Vu HT, et al. (2018) Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation. Front Cardiovasc Med 5, 23
29594152   Curated Info

3

Le NT, et al. (2013) A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis. Circulation 127, 486-99
23243209   Curated Info

4

Morimoto H, et al. (2007) Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation. J Biol Chem 282, 35449-56
17928297   Curated Info

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