Ser149
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Home > Phosphorylation Site Page: > Ser149  -  MEK5 (human)

Site Information
sNSLkKssAELKkIL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455512

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 )
Relevant cell line - cell type - tissue:
A498 (renal) ( 3 ) , HeLa_Meta (cervical) ( 2 ) , HeLa_Pro (cervical) ( 2 ) , HeLa_Telo (cervical) ( 2 ) , MDA-MB-435S (breast cell) ( 4 )

Upstream Regulation
Kinases, in vitro:
ERK5 (human) ( 5 )
Treatments:
MG132 ( 2 )

References 

1

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

2

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

3

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

4

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

5

Mody N, et al. (2003) An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro. Biochem J 372, 567-75
12628002   Curated Info