Ser30

Site Information
EDLQEVLssDENGGT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455503

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 ) , HeLa (cervical) ( 2 ) , macrophage-bone marrow ( 1 ) , RAW 264.7 (macrophage) ( 1 )

Downstream Regulation
Effects of modification on DDIT3:	activity, inhibited ( 2 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	transcription, inhibited ( 2 )

References
1	Dai X, et al. (2016) Phosphorylation of CHOP (C/EBP Homologous Protein) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ Res 119, 1089-1100 27650555 Curated Info
2	Ubeda M, Habener JF (2003) CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation. J Biol Chem 278, 40514-20 12876286 Curated Info