Ser1387
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Home > Phosphorylation Site Page: > Ser1387  -  BRCA1 (human)

Site Information
EDCSGLSsQSDILTT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455495

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , electrophoretic mobility shift ( 7 ) , mutation of modification site ( 1 , 3 , 4 , 5 ) , phospho-antibody ( 2 , 3 , 6 , 7 ) , western blotting ( 1 , 2 , 3 , 7 )
Disease tissue studied:
ataxia-telangiectasia ( 7 ) , brain cancer ( 3 ) , glioblastoma ( 3 ) , glioma ( 3 ) , breast cancer ( 1 , 2 , 3 ) , breast ductal carcinoma ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
NBS1 (human) ( 2 ) , RAP80 (human) ( 2 )
Putative in vivo kinases:
ATM (human) ( 3 , 6 , 7 )
Kinases, in vitro:
ATM (human) ( 7 , 8 )
Treatments:
DIM ( 3 ) , ionizing_radiation ( 5 , 6 , 7 ) , UV ( 6 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 1 , 2 , 5 ) , DNA repair, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ataxia-telangiectasia ( 7 )

References 

1

Beckta JM, et al. (2015) Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget 6, 27674-87
26320175   Curated Info

2

Goldstein M, Kastan MB (2015) Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res 75, 2699-707
25939603   Curated Info

3

Fan S, et al. (2009) Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res 69, 6083-91
19622773   Curated Info

4

Zhang F, et al. (2009) PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol 19, 524-9
19268590   Curated Info

5

Xu B, O'Donnell AH, Kim ST, Kastan MB (2002) Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res 62, 4588-91
12183412   Curated Info

6

Gatei M, et al. (2001) Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem 276, 17276-80
11278964   Curated Info

7

Gatei M, et al. (2000) Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res 60, 3299-304
10866324   Curated Info

8

Kim ST, Lim DS, Canman CE, Kastan MB (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274, 37538-43
10608806   Curated Info