Ser916
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Home > Phosphorylation Site Page: > Ser916  -  PRKD1 (rat)

Site Information
KALSERVsIL_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447632

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:
adrenal cancer ( 3 ) , pheochromocytoma ( 3 )
Relevant cell line - cell type - tissue:
fibroblast-heart ( 1 ) , IEC-18 (epithelial) ( 6 ) , IEC-6 (epithelial) ( 6 ) , myocyte-heart ( 1 ) , pancreatic acini ( 2 ) , parotid acinar-salivary gland ( 5 ) , PC-12 (chromaffin) ( 3 ) , RALA255-10G (hepatocyte) ( 4 )

Upstream Regulation
Regulatory protein:
PRKD1 (rat) ( 1 )
Putative in vivo kinases:
PRKD1 (rat) ( 3 )
Kinases, in vitro:
PRKD1 (rat) ( 3 , 6 )
Treatments:
AG1478 ( 1 ) , AG527 ( 2 ) , angiotensin ( 6 ) , bisindolylmaleimide ( 6 ) , bombesin ( 2 ) , BzATP ( 5 ) , cAMP_analog ( 2 ) , carbachol ( 2 , 5 ) , CCK-JMV ( 2 ) , cholecystokinin ( 2 ) , EGF ( 2 ) , endothelin ( 2 ) , FGF2 ( 2 ) , GF109203X ( 1 , 2 , 3 , 5 ) , Go_6976 ( 1 , 2 ) , Go_6983 ( 2 ) , HGF ( 2 ) , IGF-1 ( 2 ) , insulin ( 2 ) , isoproterenol ( 1 ) , LPA ( 6 ) , LY294002 ( 2 ) , norepinephrine ( 1 ) , Pasteurella_multocida_toxin ( 1 ) , PD98059 ( 2 ) , PDGF ( 2 ) , phorbol_ester ( 1 , 2 , 3 , 5 , 6 ) , PKC-zeta_inhibitor ( 2 ) , PP2 ( 2 ) , PP3 ( 2 ) , prazosin ( 1 ) , propranolol ( 1 ) , Ro31-8220 ( 6 ) , secretin human ( 2 ) , substance_P ( 5 ) , TGF-beta ( 2 ) , thapsigargin ( 2 ) , thrombin ( 1 ) , U0126 ( 1 , 2 ) , U73122 ( 2 ) , U73343 ( 2 ) , VEGF ( 2 ) , VIP ( 2 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on PRKD1:
intracellular localization ( 1 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
transcription, altered ( 1 )
Inhibit interaction with:
KIDINS220 (rat) ( 3 )

References 

1

Ozgen N, et al. (2008) Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart. J Biol Chem 283, 17009-19
18378685   Curated Info

2

Berna MJ, et al. (2007) CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim Biophys Acta 1773, 483-501
17306383   Curated Info

3

Sánchez-Ruiloba L, et al. (2006) Protein kinase D intracellular localization and activity control kinase D-interacting substrate of 220-kDa traffic through a postsynaptic density-95/discs large/zonula occludens-1-binding motif. J Biol Chem 281, 18888-900
16651260   Curated Info

4

Wang Y, et al. (2004) Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. J Biol Chem 279, 31089-97
15145937   Curated Info

5

Bradford MD, Soltoff SP (2002) P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Biochem J 366, 745-55
12057008   Curated Info

6

Chiu T, Rozengurt E (2001) PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC. Am J Physiol Cell Physiol 280, C929-42
11245610   Curated Info