Ser744
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Home > Phosphorylation Site Page: > Ser744  -  PRKD1 (rat)

Site Information
ARIIGEKsFRRsVVG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448589

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:
lymphoma ( 6 ) , B cell lymphoma ( 6 )
Relevant cell line - cell type - tissue:
'neuron, striatal' ( 1 ) , 293 (epithelial) ( 6 ) , A20 (B lymphocyte) ( 6 ) , COS (fibroblast) ( 6 ) , fibroblast-heart ( 2 ) , MDCK (epithelial) ( 6 ) , myocyte-heart ( 2 ) , pancreatic acini ( 3 ) , parotid acinar-salivary gland ( 5 ) , RALA255-10G (hepatocyte) ( 4 ) , Rat1 (fibroblast) ( 6 ) , Swiss 3T3 (fibroblast) ( 6 )

Upstream Regulation
Putative in vivo kinases:
PKCD (rat) ( 3 ) , PKCE (mouse) ( 6 ) , PKCH (mouse) ( 6 ) , PRKD1 (human) ( 1 )
Treatments:
AG1478 ( 2 ) , AG527 ( 3 ) , bisindolylmaleimide ( 4 ) , bombesin ( 3 , 6 ) , BzATP ( 5 ) , cAMP_analog ( 3 ) , carbachol ( 3 , 5 ) , CCK-JMV ( 3 ) , cholecystokinin ( 3 ) , cocaine ( 1 ) , deltaV1-1 ( 3 ) , EGF ( 3 ) , endothelin ( 3 ) , FGF2 ( 3 ) , GF109203X ( 2 , 3 , 5 , 6 ) , Go_6976 ( 3 ) , Go_6983 ( 3 ) , HGF ( 3 ) , IGF-1 ( 3 ) , insulin ( 3 ) , isoproterenol ( 2 ) , LY294002 ( 3 ) , menadione ( 4 ) , norepinephrine ( 2 ) , Pasteurella_multocida_toxin ( 2 ) , PD98059 ( 3 ) , PDGF ( 3 ) , phorbol_ester ( 2 , 3 , 5 , 6 ) , PKC-epsilon_translocation_inhibitor ( 3 ) , PKC-zeta_inhibitor ( 3 ) , PP2 ( 3 ) , PP3 ( 3 ) , prazosin ( 2 ) , propranolol ( 2 ) , secretin human ( 3 ) , substance_P ( 5 ) , TGF-beta ( 3 ) , thapsigargin ( 3 ) , thrombin ( 2 ) , U0126 ( 2 , 3 , 4 ) , U73122 ( 3 ) , U73343 ( 3 ) , VEGF ( 3 ) , VIP ( 3 ) , wortmannin ( 3 )

Downstream Regulation
Effects of modification on PRKD1:
enzymatic activity, induced ( 6 )

References 

1

Wang N, et al. (2014) Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacology 39, 1290-301
24362306   Curated Info

2

Ozgen N, et al. (2008) Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart. J Biol Chem 283, 17009-19
18378685   Curated Info

3

Berna MJ, et al. (2007) CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim Biophys Acta 1773, 483-501
17306383   Curated Info

4

Wang Y, et al. (2004) Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. J Biol Chem 279, 31089-97
15145937   Curated Info

5

Bradford MD, Soltoff SP (2002) P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Biochem J 366, 745-55
12057008   Curated Info

6

Waldron RT, et al. (2001) Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo. J Biol Chem 276, 32606-15
11410586   Curated Info