Ser343
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Home > Phosphorylation Site Page: > Ser343  -  QIK (human)

Site Information
RLKSHRssFPVEQRL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2150903

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 4 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 , 3 ) , ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 ) , 293 (epithelial) ( 4 ) , adipocyte ( 1 ) , adipocyte-adipose tissue ( 4 ) , breast ( 2 , 3 ) , HEK293T (epithelial) ( 1 ) , SKOV-3 (ovarian) ( 1 )

Upstream Regulation
Kinases, in vitro:
QIK (human) ( 1 )

Downstream Regulation
Effects of modification on QIK:
enzymatic activity, induced ( 1 )

References 

1

Miranda F, et al. (2016) Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche. Cancer Cell 30, 273-89
27478041   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Henriksson E, et al. (2012) The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes. Biochem J 444, 503-14
22462548   Curated Info

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