Thr187
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Home > Phosphorylation Site Page: > Thr187  -  TAK1 (rat)

Site Information
CDIQtHMtNNKGSAA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454704

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
aorta ( 1 ) , myocyte-heart ( 2 ) , VSMC ('muscle, smooth') ( 1 )

Upstream Regulation
Putative upstream phosphatases:
PPP3CA (human) ( 2 )
Treatments:
injury ( 1 ) , PDGF ( 1 ) , TAK1_inhibitor ( 1 )

Downstream Regulation
Effects of modification on TAK1:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
autophagy, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 )

References 

1

Zheng X, et al. (2022) TAK1 accelerates transplant arteriosclerosis in rat aortic allografts by inducing autophagy in vascular smooth muscle cells. Atherosclerosis 343, 10-19
35078016   Curated Info

2

Liu Q, Busby JC, Molkentin JD (2009) Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol 11, 154-61
19136967   Curated Info