Ser10
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Home > Phosphorylation Site Page: > Ser10  -  Vimentin (human)

Site Information
trsVssssyrrMFGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455451

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 11 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 10 , 11 ) , mutation of modification site ( 9 ) , peptide sequencing ( 11 ) , phosphopeptide mapping ( 11 ) , western blotting ( 9 )
Disease tissue studied:
breast cancer ( 3 ) , cervical cancer ( 8 ) , cervical adenocarcinoma ( 8 ) , laryngeal cancer ( 10 ) , lung cancer ( 5 ) , non-small cell lung cancer ( 5 ) , pancreatic ductal adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 4 ) , 786-O (renal) [VHL (human), transfection] ( 2 ) , 786-O (renal) ( 2 ) , A498 (renal) ( 7 ) , BHK-21 (fibroblast) ( 11 ) , HeLa (cervical) ( 6 ) , HeLa S3 (cervical) ( 8 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 3 ) , HMLER ('stem, breast cancer') ( 3 ) , HOP62 (pulmonary) ( 5 ) , larynx ( 10 ) , macrophage-bone marrow ( 9 ) , NCI-H322 (pulmonary) ( 5 ) , Vero E6-S ('epithelial, kidney') ( 1 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 11 )
Treatments:
calyculin_A ( 11 ) , nocodazole ( 8 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, altered ( 9 )

References 

1

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182
32645325   Curated Info

2

Malec V, Coulson JM, Urbé S, Clague MJ (2015) Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells. J Proteome Res 14, 5263-72
26506913   Curated Info

3

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

4

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

5

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

6

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

7

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

8

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

9

Barberis L, et al. (2009) Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin. Eur J Immunol 39, 1136-46
19291697   Curated Info

10

Stokes M (2008) CST Curation Set: 4310; Year: 2008; Biosample/Treatment: tissue, larynx/untreated; Disease: laryngeal cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

11

Eriksson JE, et al. (2004) Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments. J Cell Sci 117, 919-32
14762106   Curated Info

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