Ser47
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Home > Phosphorylation Site Page: > Ser47  -  Vimentin (mouse)

Site Information
LGsALRPstsRsLys   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455455

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 , 6 )
Disease tissue studied:
bladder cancer ( 6 ) , neuroblastoma ( 4 )
Relevant cell line - cell type - tissue:
'fat, brown' ( 5 ) , epithelial-lens [Vimentin (mouse), genetic knockin] ( 1 ) , kidney ( 5 ) , lung ( 5 ) , macrophage-peritoneum ( 2 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 3 ) , N1E-115 (neuron) ( 4 ) , spleen ( 5 ) , T24 (bladder cell) ( 6 )

Upstream Regulation
Kinases, in vitro:
AurB (mouse) ( 6 ) , PKACA (mouse) ( 7 )
Treatments:
LPA ( 4 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 6 )

References 

1

Matsuyama M, et al. (2013) Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells. J Biol Chem 288, 35626-35
24142690   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

4

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

6

Goto H, et al. (2003) Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem 278, 8526-30
12458200   Curated Info

7

Ando S, et al. (1989) Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure. Biochemistry 28, 2974-9
2500966   Curated Info

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