Ser491
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Home > Phosphorylation Site Page: > Ser491  -  CDT1 (human)

Site Information
GSCCTIMsPGEMEKH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21440505

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 3 ) , fibroblast ( 3 ) , HCT116 (intestinal) ( 3 ) , HeLa (cervical) ( 1 , 3 ) , Jurkat (T lymphocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 3 ) , P38A (human) ( 3 )
Kinases, in vitro:
P38A (human) ( 3 )
Treatments:
nocodazole ( 3 ) , SB203580 ( 3 ) , sorbitol ( 3 ) , UV ( 3 )

Downstream Regulation
Effects of modification on CDT1:
activity, inhibited ( 3 ) , molecular association, regulation ( 3 ) , protein stabilization ( 3 )
Inhibit interaction with:
RAMP (human) ( 3 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Chandrasekaran S, Tan TX, Hall JR, Cook JG (2011) Stress-stimulated mitogen-activated protein kinases control the stability and activity of the cdt1 DNA replication licensing factor. Mol Cell Biol 31, 4405-16
21930785   Curated Info