Thr406
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Home > Phosphorylation Site Page: > Thr406  -  CDT1 (human)

Site Information
LPAtPPAtPPAAsPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21440503

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
bone cancer ( 1 ) , colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 3 ) , fibroblast ( 3 ) , HCT116 (intestinal) ( 3 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 , 2 , 3 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 3 ) , P38A (human) ( 3 )
Kinases, in vitro:
CDK1 (human) ( 1 ) , P38A (human) ( 3 )
Treatments:
calyculin_A ( 1 ) , CVT-313 ( 1 ) , JNK_inhibitor_VIII ( 1 ) , nocodazole ( 1 , 3 ) , okadaic_acid ( 1 ) , RO-3306 ( 1 ) , SB203580 ( 1 , 3 ) , sorbitol ( 3 ) , UV ( 3 )

Downstream Regulation
Effects of modification on CDT1:
activity, inhibited ( 3 ) , molecular association, regulation ( 1 , 3 ) , phosphorylation ( 1 ) , protein stabilization ( 3 )
Inhibit interaction with:
MCM2 (human) ( 1 ) , RAMP (human) ( 3 )

References 

1

Zhou Y, et al. (2020) Distinct and sequential re-replication barriers ensure precise genome duplication. PLoS Genet 16, e1008988
32841231   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Chandrasekaran S, Tan TX, Hall JR, Cook JG (2011) Stress-stimulated mitogen-activated protein kinases control the stability and activity of the cdt1 DNA replication licensing factor. Mol Cell Biol 31, 4405-16
21930785   Curated Info