Ser49
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Home > Phosphorylation Site Page: > Ser49  -  Bcl-xL (human)

Site Information
ESEMEtPsAINGNPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21336504

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK3 (human) ( 3 )
Kinases, in vitro:
PLK3 (human) ( 3 )
Treatments:
blebbistatin ( 3 ) , etoposide ( 3 ) , MG132 ( 3 ) , nocodazole ( 3 ) , thymidine ( 3 )

Downstream Regulation
Effects of modification on Bcl-xL:
protein conformation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 2 , 3 ) , cell growth, inhibited ( 2 )

References 

1

Priya P, Maity A, Ghosh Dastidar S (2017) The long unstructured region of Bcl-xl modulates its structural dynamics. Proteins 85, 1567-1579
28486788   Curated Info

2

Baruah PS, Beauchemin M, H├ębert J, Bertrand R (2016) Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts. PLoS One 11, e0159091
27398719   Curated Info

3

Wang J, Beauchemin M, Bertrand R (2011) Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. Cell Signal 23, 2030-8
21840391   Curated Info