Ser391
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Home > Phosphorylation Site Page: > Ser391  -  CDT1 (human)

Site Information
LRSAAPssPGsPrPA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20804632

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 , 5 ) , mutation of modification site ( 3 ) , western blotting ( 4 )
Disease tissue studied:
colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 3 ) , fibroblast ( 3 ) , HCT116 (intestinal) ( 3 ) , HeLa (cervical) ( 3 , 4 ) , Jurkat (T lymphocyte) ( 5 ) , K562 (erythroid) ( 2 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 3 ) , P38A (human) ( 3 )
Kinases, in vitro:
P38A (human) ( 3 )
Treatments:
JNK_inhibitor_I ( 4 ) , nocodazole ( 3 ) , SB203580 ( 3 ) , sorbitol ( 3 , 4 ) , SP600125 ( 4 ) , UV ( 3 )

Downstream Regulation
Effects of modification on CDT1:
activity, inhibited ( 3 ) , molecular association, regulation ( 3 ) , protein stabilization ( 3 )
Inhibit interaction with:
RAMP (human) ( 3 )

References 

1

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Chandrasekaran S, Tan TX, Hall JR, Cook JG (2011) Stress-stimulated mitogen-activated protein kinases control the stability and activity of the cdt1 DNA replication licensing factor. Mol Cell Biol 31, 4405-16
21930785   Curated Info

4

Miotto B, Struhl K (2011) JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol Cell 44, 62-71
21856198   Curated Info

5

Possemato A (2008) CST Curation Set: 5275; Year: 2008; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P , PTMScan(R) PLK Binding Motif (SpTP) Immunoaffinity Beads Cat#: 1995
Curated Info