Tyr364
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Home > Phosphorylation Site Page: > Tyr364  -  IL2RB (human)

Site Information
SCFTNQGyFFFHLPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455360

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 3 , 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
IL-2 ( 3 )

Downstream Regulation
Effects of modification on IL2RB:
molecular association, regulation ( 2 , 3 , 4 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
SHC1 (human) ( 2 , 3 , 4 )

References 

1

Lindemann MJ, et al. (2008) Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem 283, 14100-8
18348982   Curated Info

2

Delespine-Carmagnat M, Bouvier G, Bertoglio J (2000) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. Eur J Immunol 30, 59-68
10602027   Curated Info

3

Ravichandran KS, et al. (1996) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A 93, 5275-80
8643566   Curated Info

4

Evans GA, et al. (1995) Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem 270, 28858-63
7499411   Curated Info