Ser158
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Home > Phosphorylation Site Page: > Ser158  -  CTBP1 (human)

Site Information
REGTRVQsVEQIREV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455351

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , [32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 3 , 4 ) , western blotting ( 3 )
Disease tissue studied:
breast cancer ( 4 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , breast ( 1 ) , MCF-7 (breast cell) ( 4 ) , NCI-H295R ( 3 )

Upstream Regulation
Putative in vivo kinases:
PAK1 (human) ( 4 )
Kinases, in vitro:
AMPKA1 (human) ( 2 ) , PAK1 (human) ( 4 ) , PAK6 (human) ( 3 )
Treatments:
EGF ( 4 ) , serum ( 4 ) , siRNA ( 4 )

Downstream Regulation
Effects of modification on CTBP1:
enzymatic activity, inhibited ( 4 ) , intracellular localization ( 2 , 4 ) , molecular association, regulation ( 3 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
transcription, altered ( 4 ) , transcription, induced ( 2 , 3 )
Inhibit interaction with:
STF-1 (human) ( 3 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Kim JH, et al. (2013) AMP-activated protein kinase phosphorylates CtBP1 and down-regulates its activity. Biochem Biophys Res Commun 431, 8-13
23291169   Curated Info

3

Dammer EB, Sewer MB (2008) Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem 283, 6925-34
18184656   Curated Info

4

Barnes CJ, et al. (2003) Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol 10, 622-8
12872159   Curated Info

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