Ser676
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Home > Phosphorylation Site Page: > Ser676  -  NFAT3 (human)

Site Information
SNGRRKRsPTQSFRF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455348

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , BHK-21 (fibroblast) ( 1 ) , COS (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 ) , RSK2 (human) ( 1 )
Kinases, in vitro:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 ) , RSK2 (human) ( 1 )
Treatments:
ionomycin ( 1 ) , phorbol_ester ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on NFAT3:
activity, induced ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Yang TT, et al. (2005) Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex. Mol Cell Biol 25, 907-20
15657420   Curated Info