Lys274
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Home > Ubiquitylation Site Page: > Lys274  -  WWOX (human)

Site Information
DINDSLGkLDFSRLS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21188582

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
hydroxyurea ( 1 ) , UVC ( 1 )

Downstream Regulation
Effects of modification on WWOX:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , DNA repair, induced ( 1 )
Induce interaction with:
ATM (human) ( 1 )

References 

1

Abu-Odeh M, Hereema NA, Aqeilan RI (2016) WWOX modulates the ATR-mediated DNA damage checkpoint response. Oncotarget 7, 4344-55
26675548   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Udeshi ND, et al. (2013) Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Mol Cell Proteomics 12, 825-31
23266961   Curated Info

4

Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 44, 325-40
21906983   Curated Info