Lys443
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Home > Ubiquitylation Site Page: > Lys443  -  Ku80 (human)

Site Information
ssLkNSKkYAPTEAQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21177862

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 4 , 5 , 6 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Disease tissue studied:
bone cancer ( 3 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Ku80:
molecular association, regulation ( 3 )
Effects of modification on biological processes:
DNA repair, induced ( 3 )
Inhibit interaction with:
DNA ( 3 )

References 

1

Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640
29967540   Curated Info

2

Lumpkin RJ, et al. (2017) Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun 8, 1171
29079793   Curated Info

3

Ishida N, et al. (2017) Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair. Mol Cell Biol 37
27895153   Curated Info

4

Udeshi ND, et al. (2013) Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Mol Cell Proteomics 12, 825-31
23266961   Curated Info

5

Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 44, 325-40
21906983   Curated Info

6

Wagner SA, et al. (2011) A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles. Mol Cell Proteomics 10, M111.013284
21890473   Curated Info