Ser94
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Home > Phosphorylation Site Page: > Ser94  -  Spinophilin (mouse)

Site Information
SDRGVRLsLPRAssL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448728

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 3 , 4 , 5 ) , western blotting ( 1 , 3 , 4 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 3 ) , 'brain, neostriatum' ( 5 ) , 'brain, striatum' ( 3 , 4 ) , NE-4C (neuroepithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (mouse) ( 1 )
Kinases, in vitro:
PKACA (human) ( 5 )
Putative upstream phosphatases:
PPP1CA (human) ( 5 ) , PPP2CA (human) ( 5 )
Treatments:
AMPA ( 5 ) , caffeine ( 4 ) , CGS_21680 ( 4 , 5 ) , ciclosporin ( 5 ) , colforsin ( 4 ) , isoflurane ( 3 ) , ketamine ( 3 ) , KT5720 ( 1 ) , NKH_477 ( 1 ) , NMDA ( 5 ) , okadaic_acid ( 5 ) , PGE2 ( 1 ) , propofol ( 3 ) , quinpirole ( 5 ) , SKF81297 ( 5 )

Downstream Regulation
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , cytoskeletal reorganization ( 1 )

References 

1

Kissoondoyal A, Crawford DA (2021) Prostaglandin E2 Increases Neurite Length and the Formation of Axonal Loops, and Regulates Cone Turning in Differentiating NE4C Cells Via PKA. Cell Mol Neurobiol
33389417   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Snyder GL, Galdi S, Hendrick JP, Hemmings HC (2007) General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology 53, 619-30
17826804   Curated Info

4

Sahin B, et al. (2007) Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling. Brain Res 1129, 1-14
17157277   Curated Info

5

Uematsu K, et al. (2005) Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways. J Neurochem 95, 1642-52
16300646   Curated Info

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