Ser945
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser945  -  claspin (human)

Site Information
EELLNLCsGkFtsQD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455335

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on claspin:
molecular association, regulation ( 4 )
Induce interaction with:
Chk1 (human) ( 4 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

3

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A (2009) Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. J Biol Chem 284, 33107-14
19828454   Curated Info

4

Clarke CA, Clarke PR (2005) DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J 388, 705-12
15707391   Curated Info