Thr916
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Home > Phosphorylation Site Page: > Thr916  -  claspin (human)

Site Information
DELLDLCtGKFTsQA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455334

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 2 )
Kinases, in vitro:
Chk1 (human) ( 2 )
Treatments:
caffeine ( 2 ) , hydroxyurea ( 2 ) , UCN-01 ( 2 ) , UV ( 2 )

Downstream Regulation
Effects of modification on claspin:
molecular association, regulation ( 3 )
Effects of modification on biological processes:
chromatin organization, altered ( 2 )
Induce interaction with:
Chk1 (human) ( 3 )

References 

1

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A (2009) Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. J Biol Chem 284, 33107-14
19828454   Curated Info

2

Chini CC, Chen J (2006) Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 281, 33276-82
16963448   Curated Info

3

Clarke CA, Clarke PR (2005) DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J 388, 705-12
15707391   Curated Info