Ser445
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Home > Phosphorylation Site Page: > Ser445  -  RARA (human)

Site Information
APPPGSCsPSLSPSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455329

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 3 ) , western blotting ( 3 , 4 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , liver cancer ( 3 ) , hepatocellular carcinoma ( 3 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , HeLa (cervical) ( 4 ) , Huh7 (hepatic) ( 3 )

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 3 )
Kinases, in vitro:
JNK1 (human) ( 4 )
Treatments:
anisomycin ( 3 ) , SP600125 ( 3 )

Downstream Regulation
Effects of modification on RARA:
protein degradation ( 3 , 4 ) , ubiquitination ( 3 , 4 )
Effects of modification on biological processes:
signaling pathway regulation ( 3 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

3

Hoshikawa Y, et al. (2011) c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells. Cancer Sci 102, 934-41
21272161   Curated Info

4

Srinivas H, et al. (2005) c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha. Mol Cell Biol 25, 1054-69
15657432   Curated Info